Electroacupuncture Attenuates Inflammation after Ischemic Stroke by Inhibiting NF-κB-Mediated Activation of Microglia⁠


“Electroacupuncture (EA) may reduce inflammatory injury by inhibiting nuclear factor-kappa B (NF-κB) signaling pathway activation after ischemic stroke… upregulating neuronal CYLD expression by EA may prevent NF-κB nuclear translocation and decrease neuronal CX3CL1 expression, inducing subsequent inhibition of microglial activation and pro-inflammatory cytokines in peri-ischemic areas.”⁠

MOAs evaluated in the study:⁠
– “…EA caused a substantial drop in CYLD protein at 6 h reperfusion”⁠
– “EA inhibited the p38 MAPK signaling pathway in the hippocampus of rats with cerebral ischemia/reperfusion injury”⁠
– “EA increased the number of neuronal CYLD-positive cells in the ischemic cortical border region at 24 h reperfusion.”⁠
– “EA inhibited degradation of IκBα and NF-κB nuclear translocation by increasing CYLD. CYLD and NF-κB p65 were co-expressed in cortical neurons of the peri-ischemic area and more CYLD positive cells were observed there, but NF-κB p65 was primarily maintained in the cytoplasm after EA treatment during the acute stage of ischemia/reperfusion”⁠
– “CYLD inhibited the NF-κB signaling pathway…”⁠

Chinese Medicine IS evidence based medicine. Acupuncture and Chinese herbal formulas have been used for 1000’s of years in a wide variety of conditions…
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Electroacupuncture Attenuates Inflammation after Ischemic Stroke by Inhibiting NF-κB-Mediated Activation of Microglia⁠
http://downloads.hindawi.com/journals/ecam/2020/8163052.pdf⁠
PMID: 29163038⁠


About Peter Lecke L.Ac., CFMP, Dipl.O.M.

Peter Lecke, MSTOM, L.Ac., CFMP, Dipl. O.M. is a California Acupuncture Board Licensed Acupuncturist, Herbalist, and Functional Medicine practitioner. He is passionate about health, wellness, and practicing medicine with compassion and genuine connection. Peter specializes in the treatment of Auto-immune and Inflammatory disorders. He also has extensive experience treating all types of Acute and Chronic Pain Conditions as well as many other conditions such as: Digestive Health, Stress related conditions, Dermatological conditions, Lifestyle Changes, Women’s Health, and much more. Peter believes in the principle of facilitating good health by promoting and restoring balance and integration of the body's natural systems. He has helped hundreds of people enjoy good health and wellbeing with Acupuncture, Chinese Medicine, and Functional Medicine…