“Electroacupuncture (EA) may reduce inflammatory injury by inhibiting nuclear factor-kappa B (NF-κB) signaling pathway activation after ischemic stroke… upregulating neuronal CYLD expression by EA may prevent NF-κB nuclear translocation and decrease neuronal CX3CL1 expression, inducing subsequent inhibition of microglial activation and pro-inflammatory cytokines in peri-ischemic areas.”
MOAs evaluated in the study:
– “…EA caused a substantial drop in CYLD protein at 6 h reperfusion”
– “EA inhibited the p38 MAPK signaling pathway in the hippocampus of rats with cerebral ischemia/reperfusion injury”
– “EA increased the number of neuronal CYLD-positive cells in the ischemic cortical border region at 24 h reperfusion.”
– “EA inhibited degradation of IκBα and NF-κB nuclear translocation by increasing CYLD. CYLD and NF-κB p65 were co-expressed in cortical neurons of the peri-ischemic area and more CYLD positive cells were observed there, but NF-κB p65 was primarily maintained in the cytoplasm after EA treatment during the acute stage of ischemia/reperfusion”
– “CYLD inhibited the NF-κB signaling pathway…”
Chinese Medicine IS evidence based medicine. Acupuncture and Chinese herbal formulas have been used for 1000’s of years in a wide variety of conditions…
MOAs evaluated in the study:
– “…EA caused a substantial drop in CYLD protein at 6 h reperfusion”
– “EA inhibited the p38 MAPK signaling pathway in the hippocampus of rats with cerebral ischemia/reperfusion injury”
– “EA increased the number of neuronal CYLD-positive cells in the ischemic cortical border region at 24 h reperfusion.”
– “EA inhibited degradation of IκBα and NF-κB nuclear translocation by increasing CYLD. CYLD and NF-κB p65 were co-expressed in cortical neurons of the peri-ischemic area and more CYLD positive cells were observed there, but NF-κB p65 was primarily maintained in the cytoplasm after EA treatment during the acute stage of ischemia/reperfusion”
– “CYLD inhibited the NF-κB signaling pathway…”
Chinese Medicine IS evidence based medicine. Acupuncture and Chinese herbal formulas have been used for 1000’s of years in a wide variety of conditions…
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Electroacupuncture Attenuates Inflammation after Ischemic Stroke by Inhibiting NF-κB-Mediated Activation of Microglia
http://downloads.hindawi.com/journals/ecam/2020/8163052.pdf
PMID: 29163038
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